Synthesis, characterisation, and evaluation of core–shell Fe 3 O 4 /SiO 2 /polypyrrole composite nanoparticles

Micro & nano letters

article

Bei Li¹  Yongsheng Qiao³  Jinhui An¹  Lazhen Shen²  Qi Ma²  Yong Guo² 

[1] School of Chemistry and Materials Science, Shanxi Normal University;School of Chemistry and Environmental Engineering, Institute of Applied Chemistry, Shanxi Datong University;Department of Chemistry, Xinzhou Teachers University

关键词: iron compounds;    silicon compounds;    core-shell nanostructures;    nanoparticles;    filled polymers;    nanocomposites;    nanofabrication;    superparamagnetism;    nanomagnetics;    magnetic particles;    precipitation (physical chemistry);    transmission electron microscopy;    X-ray diffraction;    Fourier transform infrared spectra;    thermal analysis;    particle size;    core-shell polypyrrole composite nanoparticles;    facile synthetic approach;    superparamagnetic nanoparticles;    coprecipitation;    Stober method;    intermediate layer coating;    solvothermal methods;    transmission electron microscopy;    X-ray diffraction;    Fourier transform infrared spectroscopy;    thermogravimetric analyses;    vibration sample magnetometer;    particle size;    magnetic saturation;    drug delivery systems;    gene delivery systems;    Fe3O4-SiO2;   

DOI  :  10.1049/mnl.2017.0907

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

The objective of the study was to develop microneedle (MN) patch, with suitable properties to ensure the delivery of a therapeutic level of lornoxicam (LXM) in a period suitable to replace parenteral administration in patients, especially those who fear needles. The used polymers were cold water-soluble polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) of low molecular weight with PEG 400 as plasticizer and Tween 80 (to enhance the release) using micro molding technique. Patches were studied for needle morphology, drug content, axial fracture force measurement and drug release while the optimized formulas were further subjected to pH measurement, folding endurance, ex vivo permeation study, histopathology study, stability study and compatibility study. The patch with 11:1 ratio of PVA to PVP, 30% solid content, 5% PEG 400 and 3% Tween 80 resulted in axial needle fracture force value of (1.35 N) which is suitable for skin penetration. The release was fast with almost 100% of drug released in 60 minutes. The permeation was enhanced significantly with a steady state flux of about 3.1 times that of the solution. The lag time of MN is shorter in comparison with ordinary patch. Histopathology studies demonstrated the safety of the formulation, both stability studies and compatibility studies showed the suitability of the formulation. The results indicated that LXM microneedle patch could enhance drug permeation while achieving fast and painless administration.

【 授权许可】

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