Glutathione and pH serial responsive functional mesoporous silica nanoparticles for drug delivery

Micro & nano letters

article

Liang He¹  Xueyan Nan¹  Tong Wang¹  Pengli Bai¹ 

[1] Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences;Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, Qingdao University;University of Science and Technology of China;Tianjin Guokeyigong Science & Technology Development Co., Ltd

关键词: carbon;    fluorescence;    drug delivery systems;    drugs;    cancer;    pH;    mesoporous materials;    biomedical materials;    nanomedicine;    nanoparticles;    nanofabrication;    silicon compounds;    polymers;    glutathione;    pH serial dual-responsive drug delivery system;    hyaluronic acid;    drug loading efficiency;    targeted delivery;    pH serial responsive functional mesoporous silica nanoparticles;    chitosan;    carbon dots;    fluorescence imaging property;    cancer treatment platform;    SiO2-C;   

DOI  :  10.1049/mnl.2019.0317

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

In this work, a novel glutathione and pH serial dual-responsive drug delivery system has been developed, which was constructed with chitosan (CS), carbon dots (CDs) and hyaluronic acid (HA) modified the mesoporous silica nanoparticles (MSNs). The system showed excellent drug loading efficiency, controlled release and targeted delivery. In addition, the platform (MSN-CS@HA-CDs) exhibited fluorescence imaging property. The prepared drug delivery system appeared to be a promising cancer treatment platform.

【 授权许可】

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