Facile preparation of cancer cell membrane vehicle loaded with indocyanine green for effective photothermal therapy of cancer

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article

Ying Sun¹  Jiang Ni¹  Yiqing Zhao¹  Qiufang Gao¹ 

[1] Department of Pharmacy, the Affiliated Hospital of Jiangnan University (original area of Wuxi Third People's Hospital)

关键词: cellular biophysics;    cancer;    radiation therapy;    laser applications in medicine;    photothermal effects;    nanoparticles;    drug delivery systems;    nanomedicine;    lung;    drugs;    particle size;    biomembranes;    effective cancer photothermal therapy;    uniform particle size;    Ccm-mediated endocytosis;    free ICG;    cancer cell membrane vehicle;    lung cancer cells;    model cell line;    photothermal agent;    indocyanine green;    A549 cells;    cellular uptake;    drug delivery system;   

DOI  :  10.1049/mnl.2020.0208

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

In this study, using the lung cancer cells (A549) as the model cell line, the authors proposed a facile method to prepare uniform-sized cancer cell membrane (Ccm) vehicle, which was then employed to load the photothermal agent indocyanine green (ICG) for effective cancer photothermal therapy (PTT). The as-prepared Ccm/ICG was demonstrated to have a uniform particle size of around 100 nm, which was capable of targeting the A549 cells through Ccm-mediated endocytosis. As a result, the Ccm/ICG increased the cellular uptake of Ce6 into A549 cells as compared to free ICG and potentiated the PTT efficacy both in vitro and in vivo, which might be a promising drug delivery system for advanced cancer therapy.

【 授权许可】

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