Micro & nano letters | |
Facile preparation of cancer cell membrane vehicle loaded with indocyanine green for effective photothermal therapy of cancer | |
article | |
Ying Sun1  Jiang Ni1  Yiqing Zhao1  Qiufang Gao1  | |
[1] Department of Pharmacy, the Affiliated Hospital of Jiangnan University (original area of Wuxi Third People's Hospital) | |
关键词: cellular biophysics; cancer; radiation therapy; laser applications in medicine; photothermal effects; nanoparticles; drug delivery systems; nanomedicine; lung; drugs; particle size; biomembranes; effective cancer photothermal therapy; uniform particle size; Ccm-mediated endocytosis; free ICG; cancer cell membrane vehicle; lung cancer cells; model cell line; photothermal agent; indocyanine green; A549 cells; cellular uptake; drug delivery system; | |
DOI : 10.1049/mnl.2020.0208 | |
学科分类:计算机科学(综合) | |
来源: Wiley | |
【 摘 要 】
In this study, using the lung cancer cells (A549) as the model cell line, the authors proposed a facile method to prepare uniform-sized cancer cell membrane (Ccm) vehicle, which was then employed to load the photothermal agent indocyanine green (ICG) for effective cancer photothermal therapy (PTT). The as-prepared Ccm/ICG was demonstrated to have a uniform particle size of around 100 nm, which was capable of targeting the A549 cells through Ccm-mediated endocytosis. As a result, the Ccm/ICG increased the cellular uptake of Ce6 into A549 cells as compared to free ICG and potentiated the PTT efficacy both in vitro and in vivo, which might be a promising drug delivery system for advanced cancer therapy.
【 授权许可】
CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
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RO202107100002483ZK.pdf | 120KB | download |