期刊论文详细信息
Micro & nano letters
Facile preparation of cancer cell membrane vehicle loaded with indocyanine green for effective photothermal therapy of cancer
article
Ying Sun1  Jiang Ni1  Yiqing Zhao1  Qiufang Gao1 
[1] Department of Pharmacy, the Affiliated Hospital of Jiangnan University (original area of Wuxi Third People's Hospital)
关键词: cellular biophysics;    cancer;    radiation therapy;    laser applications in medicine;    photothermal effects;    nanoparticles;    drug delivery systems;    nanomedicine;    lung;    drugs;    particle size;    biomembranes;    effective cancer photothermal therapy;    uniform particle size;    Ccm-mediated endocytosis;    free ICG;    cancer cell membrane vehicle;    lung cancer cells;    model cell line;    photothermal agent;    indocyanine green;    A549 cells;    cellular uptake;    drug delivery system;   
DOI  :  10.1049/mnl.2020.0208
学科分类:计算机科学(综合)
来源: Wiley
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【 摘 要 】

In this study, using the lung cancer cells (A549) as the model cell line, the authors proposed a facile method to prepare uniform-sized cancer cell membrane (Ccm) vehicle, which was then employed to load the photothermal agent indocyanine green (ICG) for effective cancer photothermal therapy (PTT). The as-prepared Ccm/ICG was demonstrated to have a uniform particle size of around 100 nm, which was capable of targeting the A549 cells through Ccm-mediated endocytosis. As a result, the Ccm/ICG increased the cellular uptake of Ce6 into A549 cells as compared to free ICG and potentiated the PTT efficacy both in vitro and in vivo, which might be a promising drug delivery system for advanced cancer therapy.

【 授权许可】

CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND   

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