Green synthesised-gold nanoparticles in photothermal therapy of breast cancer

Micro & nano letters

article

Yiing Yee Foo¹  Wen Shang Saw²  Vengadesh Periasamy³  Wu Yi Chong⁴  Sri Nurestri Abd Malek¹  Saad Tayyab¹ 

[1] Institute of Biological Sciences, Faculty of Science, University of Malaya;Department of Pharmacy, Faculty of Medicine, University of Malaya;Low Dimensional Materials Research Centre (LDMRC), Department of Physics, Faculty of Science, University of Malaya;Photonics Research Centre, Faculty of Science, University of Malaya;Centre of Research for Computational Sciences and Informatics for Biology, Agriculture and Healthcare (CRYSTAL), University of Malaya

关键词: photothermal effects;    nanomedicine;    cellular biophysics;    particle size;    biomedical materials;    radiation therapy;    visible spectra;    nanoparticles;    ultraviolet spectra;    gold;    cancer;    nanofabrication;    tumours;    Au;    time 120.0 s;    wavelength 532.0 nm;    higher photothermal heating efficiency;    breast cancer cells;    photothermal killing;    curcuma mangga;    photothermal therapy;    green synthesised-gold nanoparticles;    cancer therapy;    CM-AuNP-dependent photothermal-induced MCF-7 cells death;    citrate-AuNPs;    cell viability;    laser irradiation;    CM-AuNPs;   

DOI  :  10.1049/mnl.2018.5557

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

In this work, the use of gold nanoparticles (AuNPs), synthesised using Curcuma mangga (CM) extract in photothermal killing of breast cancer (MCF-7) cells is demonstrated. CM-AuNPs showed higher photothermal heating efficiency compared to citrate-AuNPs upon irradiation with a 532 nm laser. In addition, treatment of MCF-7 cells with CM-AuNPs coupled with laser irradiation for 120 s was found to significantly reduce (72%) the cell viability compared to about 13%, obtained with citrate-AuNPs. Results from flow cytometry showed that the CM-AuNP-dependent photothermal-induced MCF-7 cells death was triggered mainly by apoptosis mechanism. All these results suggested the potential use of CM-AuNPs as therapeutic agents in cancer therapy.

【 授权许可】

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