Synthesis, characterisation and antibacterial effects of sol–gel derived biphasic calcium phosphate nanopowders

Micro & nano letters

article

Zahra Nazemi¹  Masoumeh Haghbin Nazarpak²  Mehdi Mehdikhani-Nahrkhalaji⁴  Hamid Staji⁵  Mohammad Mehdi Kalani¹ 

[1] Department of Material and Metallurgical Engineering, Semnan University;New Technologies Research Center (NTRC), Amirkabir University of Technology;Mawson Institute, University of South Australia;Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan;Department of Veterinary Medicine, Semnan University

关键词: bioceramics;    antibacterial activity;    nanoparticles;    nanomedicine;    nanofabrication;    calcium compounds;    sol-gel processing;    bone;    particle size;    sintering;    X-ray diffraction;    atomic emission spectroscopy;    scanning electron microscopy;    transmission electron microscopy;    Fourier transform spectra;    infrared spectra;    decomposition;    microorganisms;    cellular biophysics;    antibacterial effects;    sol-gel derived biphasic calcium phosphate nanopowders;    hydroxyapatite;    β-tricalcium phosphate;    bone defect reconstruction;    drug delivery application;    maxillofacial application;    dental application;    orthopaedic application;    bioactivity;    bioresorbability;    biphasic calcium phosphate ceramics;    sintering temperature;    X-ray diffraction;    inductive coupled plasma-atomic emission spectroscopy;    scanning electron microscopy;    transmission electron microscopy;    Fourier transformer infrared spectrophotometer;    decomposition;    nanoparticles;    Escherichia coli;    Gram-negative bacteria;    bacterial growth reduction;    bone defect treatment;    Ca3(PO4)2;    Ca10(PO4)6(OH)2;   

DOI  :  10.1049/mnl.2013.0655

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Aim: Posthypoxic myoclonus (PHM) is a rare myoclonus syndrome observed after cardiac arrest, is difficult to control and has no definitive diagnostic method. The pathophysiological mechanism of PHM, also known as Lance Adams Syndrome (LAS), is unknown and definitive treatment options are limited. The aim of this study was to present cases of LAS and the follow-up results of treatment following cardiopulmonary resuscitation (CPR) in our hospital.Methodology: This study included patients followed up in the intensive care clinic of our hospital between May 2012 and January 2017 after CPR in the intensive care unit (ICU). A retrospective review was made of the record files of patients who were evaluated by the Neurology Department because of epileptic seizures.Results: Evaluation was made of 19 patients with no history of epilepsy/antiepileptic drug use and treatment initiated by the Neurology Clinic for LAS. The patients comprised of 11 males (58%) and 8 females (42%) with a mean age of 55.89 ± 19.65 y for survivors and 61.50 ± 16.12 years for non-survivors. The mean length of hospital stay was 35 days for survivors and 17.5 days for nonsurvivors. Outcomes were determined as, mortality in 10 cases, long-term care in 7, and discharge withrecovery in 2. Sodium valproate was used in 4 patients and levetiracetam in 15. The 7 patients onlong-term care were found to have been lost in the 3-month period after discharge.Conclusions: In Lance Adams Syndrome the EEG may not provide any pathological clue or show epileptic changes. An early start to treatment can lead to better prognosis. It can be concluded that after CPR, myoclonic contractions can be reduced, and morbidity and mortality can improvewith early diagnosis and early treatment.

【 授权许可】

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