Calcium deficiency in hydroxyapatite and its drug delivery applications

Micro & nano letters

article

Sivasankar Koppala¹  Sasikumar Swamiappan¹  Yuvaraj Gangarajula³  Lei Xu¹  Kishor Kumar Sadasivuni⁴  Deepalekshmi Ponnamma⁵  Vijayaraghavan Rajagopalan¹ 

[1] Faculty of Metallurgical and Energy Engineering, Kunming University of Science and Technology;Department of Chemistry, School of Advanced Sciences, VIT University;Mössbauer Effect Data Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences;Department of Mechanical and Industrial Engineering, Qatar University;Center for Advanced Materials, Qatar University

关键词: calcium compounds;    bioceramics;    drug delivery systems;    drugs;    nanoparticles;    particle size;    nanofabrication;    nanomedicine;    Fourier transform infrared spectra;    precipitation;    calcination;    X-ray diffraction;    scanning electron microscopy;    X-ray chemical analysis;    nanoporous materials;    porosity;    drug delivery applications;    calcium deficient hydroxyapatites;    precipitation method;    calcined samples;    Fourier transformation infrared spectroscopy;    powder X-ray diffraction;    scanning electron microscopy;    energy-dispersive X-ray spectroscopy;    phase purity;    particle size;    particle shape;    HAP structure;    ciprofloxacin;    sustained drug release;    phosphate buffer solution;    porous structure;    [Ca10−x(PO4)6(OH)2];   

DOI  :  10.1049/mnl.2016.0675

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Background:  The rapidly growing use of herbal drugs or supplements in complementary and alternative medicine as substitute for orthodox medicine both in developed and developing countries is fast gaining ground. Aim:  This study evaluated both qualitative and quantitative phytochemical constituents of  Diodia scandens  and  Phyllanthus amarus  vis-à-vis their synergistic effects on clinically isolated staphylococci. Methods:  A total of 200 wounds and burns samples were obtained from patients in the accident and emergency unit of different tertiary hospitals. Staphylococci were isolated and characterised using standard microbiological procedures. Whole plants of  D. scandens  and  P. amarus  were Soxhlet extracted with absolute ethanol. The phytochemical analysis was carried out using standard methods. Also, the minimum inhibitory concentration and bactericidal effect of the combined extracts were determined. Results:  The phytochemicals present in  D. scandens  include saponin (6.58%), tannin (2.27 mg/100g), alkaloids (10.53%) and phytin phosphorus (1.80 mg/g), while phytochemicals in  P. amarus  include saponin (9.99%), tannin (5.82 mg/100g), alkaloids (9.67%) and phytin phosphorus (2.44 mg/g), revealing their antibacterial properties and phytonutrients. The combination study showed that a synergistic effect exists between the two plants on the isolates tested compared with individual extracts alone at the concentrations used. Conclusion:  It is noteworthy that the traditional use of these plants was not only confirmed but the combination of  D. scandens  and  P. amarus  also proved more effective as antibacterial agent compared with a previous study on the same plants using single determination.

【 授权许可】

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