pH-responsive release of TiO 2 nanotube arrays/mesoporous silica composite based on tannic acid-Fe(III) complex coating

Micro & nano letters

article

Fengfen Zhang¹  Chunling Xie¹  Xiufeng Xiao¹ 

[1] Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, College of Chemistry and Materials Science, Fujian Normal University

关键词: biomedical materials;    pH;    drugs;    silicon compounds;    nanomedicine;    drug delivery systems;    nanofabrication;    mesoporous materials;    cellular biophysics;    coatings;    semiconductor nanotubes;    semiconductor materials;    organic compounds;    nanocomposites;    iron compounds;    pH-induced release;    drug release;    pH-responsive release;    simple drip coating method;    burst release;    pH-responsive drug delivery system;    TiO2 nanotube array-mesoporous silica composite;    tannic acid-Fe(III) complex coating;    coordination conditions;    Loxoprofen sodium;    biological activity;    MC3T3-E1 osteoblastic cell differentiation;    MC3T3-E1 osteoblastic cell growth;    TiO2-SiO2;   

DOI  :  10.1049/mnl.2019.0316

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

In this work, TiO 2 nanotube arrays/mesoporous silica composite coated with tannic acid-Fe(III) complex was prepared with a simple drip coating method. The coating significantly inhibited the burst release in the early stage of drug release. The coordination conditions of the material were different under different pH values. This resulted in different stabilities of the coating, thus controlling the release of Loxoprofen Sodium (LS) at different pH values to construct a pH-responsive drug delivery system. To demonstrate this principle, the authors loaded LS into the samples and triggered pH-induced release. The excellent biological activity of the samples was confirmed in vitro by the significant growth and differentiation of MC3T3-E1 osteoblastic cells. The data has shown that the samples had achieved intelligent control of drug release and would have a wide range of applications.

【 授权许可】

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