Melittin based on silica nanoparticles for Agrobacterium tumefaciens inhibition

Micro & nano letters

article

Chun-Mei Li¹  Bai-Ge Li³  Jian-Ping Yu¹ 

[1] Center for Research and Development of Fine Chemicals, Guizhou University;Institute of Biochemistry and Nutrition, Guizhou University;Food and Pharmaceutical Engineering Institute, College of Guiyang

关键词: nanoparticles;    silicon compounds;    antibacterial activity;    nanomedicine;    drugs;    drug delivery systems;    biomedical materials;    microorganisms;    organic compounds;    Agrobacterium tumefaciens inhibition;    antibacterial drug;    A;    tumefaciens inhibition zones;    melittin-conjugated silica nanoparticles;    gentamicin;    antibacterial activity;    drug molecules;    SiO2;   

DOI  :  10.1049/mnl.2014.0393

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

An effective method for Agrobacterium tumefaciens inhibition using silica nanoparticles (NPs) as the carrier and melittin as the antibacterial drug is developed. The diameters of the inhibition zones of A. tumefaciens treated with different concentrations of melittin-conjugated silica NPs, pure silica NPs, gentamicin and free melittin are determined. The results indicate that the pure silica NPs have no impact on A. tumefaciens. The melittin-conjugated silica NPs have strong antibacterial activity against A. tumefaciens. In addition, the antibacterial activity of the melittin-conjugated silica NPs is dose dependent. The diameter of the inhibition zone caused by the melittin-conjugated silica NPs is almost the same as the positive control. Compared with the free drug molecules, silica NPs as an ideal carrier can gather a large number of drug molecules on their surface so as to greatly enhance the antibacterial activity.

【 授权许可】

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