Hyaluronic acid coated hollow mesoporous silica nanoparticles for reduction-triggered drug release

Micro & nano letters

article

Yuanyuan Zhang¹  Xiang Cao¹  Shengke Xiang¹  Zhiwei Tong¹ 

[1] Jiangsu Key Laboratory of Advanced Materials Function Control Technology, School of Chemical Engineering, Huaihai Institute of Technology;Jiangsu Marine Resources Development Research Institute

关键词: silicon compounds;    cancer;    reduction (chemical);    nanofabrication;    nanocomposites;    drug delivery systems;    toxicology;    nanoparticles;    tumours;    biochemistry;    polymers;    cellular biophysics;    drugs;    coatings;    nanomedicine;    mesoporous materials;    biomedical materials;    optical microscopy;    molecular biophysics;    targeted tumour therapy;    anticancer drug doxorubicin;    central hollow cavities;    HMSNs;    high loading efficiency;    reduction-cleavable linkage;    β-cyclodextrin;    strong β-CD/adamantane host-guest interactions;    effective cancer therapy;    intracellular reductive environment;    HA modification;    drug delivery platform;    reduction-triggered drug release manner;    disulphide bond;    confocal microscopy;    HeLa cancer cells;    cytotoxicity;    biocompatibility;    antitumour activity;   

DOI  :  10.1049/mnl.2018.5141

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Graphite Coated Electrodes (GCE) based on molecularly imprinted polymers were fabricated for the selective potentiometric determination of Risperidone (Ris). The molecularly imprinted (MIP) and nonimprinted (NIP) polymers were synthesized by bulk polymerization using (Ris.) as a template, acrylic acid (AA) and acrylamide (AAm) as monomers, ethylene glycol dimethacrylate (EGDMA) as a cross-linker and benzoyl peroxide (BPO) as an initiator. The imprinted membranes and the non-imprinted membranes were prepared using dioctyl phthalate (DOP) and Dibutylphthalate (DBP) as plasticizers in PVC matrix. The membranes were coated on graphite electrodes. The MIP electrodes using (AA) and (AAm) showed a near nernstian and nernstian response with slopes of 55.2±0.1 and 59.0±0.2 mV/decade, correlation coefficient (r2) 0.9997 and 0.9999, a linear response for a concentration range of (1.0×10-6 - 1.0×10-2) M and (5.0x 10-7 to 1.0 x 10-2) M respectively. The response time of the prepared electrodes was less than 30 seconds. The electrode responses were stable in a pH range (4-8). The electrodes exhibited good selectivity over a wide range of interference. The most effective electrode (Ris-MIP GCE) was used to determine the concentration of (Ris.) in some pharmaceutical formulations. The electrodes could be successfully used within (7and13) weeks respectively without any drift.

【 授权许可】

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