Effectiveness of self-help workbook intervention on quality of life in cancer patients receiving chemotherapy: results of a randomized controlled trial

BMC Cancer

Ayako Matsuda¹  Yuko Tanabe²  Yukinori Ozaki²  Yuji Miura²  Koichi Suyama³  Toshimi Takano⁴  Noriko Ishizuka⁵  Eisuke Matsushima⁵ 

[1] Department of Hygiene and Public Health, School of Medicine, Teikyo University, Tokyo, Japan;Department of Medical Oncology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, 105-8470, Tokyo, Japan;Department of Medical Oncology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, 105-8470, Tokyo, Japan;Kumamoto University Hospital Cancer Center, Kumamoto, Japan;Department of Medical Oncology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, 105-8470, Tokyo, Japan;Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan;Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan;

关键词: Breast cancer;    Chemotherapy;    Colorectal cancer;    Gastric cancer;    Lung cancer;    Patient-reported outcome;    Psycho-oncology;    Psychosocial support system;   

DOI  :  10.1186/s12885-021-08333-2

来源: Springer

【 摘 要 】

BackgroundA self-help workbook is expected to support cancer patients to cope with physical and psychosocial distress, to facilitate communication with medical staff, and to improve quality of life (QOL). We conducted a randomized controlled trial to evaluate the effectiveness of a self-help workbook intervention on QOL and survival.MethodsFrom June 2014 to March 2015, patients with breast, colorectal, gastric, and lung cancer receiving outpatient chemotherapy were randomized into an intervention group (n = 100) or control group (n = 100). Intervention group participants received workbooks originally made for this study, read advice on how to cope with distress, and filled out questionnaires on the workbooks periodically. EORTC QLQ-C30 was evaluated at baseline, at 12 weeks, and at 24 weeks. The primary endpoint was Global Health Status / QOL scale (GQOL).ResultsNo significant interaction was observed between the intervention and time in terms of GQOL or any of the functional scales. Among the 69 patients who continued cytotoxic chemotherapy at 24 weeks, the intervention was significantly associated with improved emotional functioning scores (P = 0.0007). Overall survival was not significantly different between the two groups.ConclusionsSelf-help workbook intervention was feasible in cancer patients receiving chemotherapy. Although the effect of the intervention was limited, a post-hoc subset analysis suggested that the intervention may improve emotional functioning among patients who receive long-term cytotoxic chemotherapy.Trial registrationUMIN Clinical Trials Registry, UMIN000012842. Registered 14 January 2014.

【 授权许可】

CC BY