Variability of risk factors and diabetes complications

Cardiovascular Diabetology

Francesco Prattichizzo¹  Antonio Ceriello¹ 

[1] IRCCS MultiMedica, Via Gaudenzio Fantoli, 16/15, 20138, Milan, Italy;

关键词: Diabetes mellitus;    Glucose variability;    Blood pressure variability;    Lipids variability;    Body weight variability;    Uric acid variability;    Heart rate variability;    Oxidative stress;    Cardiovascular complications;    Microvascular complications;   

DOI  :  10.1186/s12933-021-01289-4

来源: Springer

【 摘 要 】

Several studies suggest that, together with glucose variability, the variability of other risk factors, as blood pressure, plasma lipids, heart rate, body weight, and serum uric acid, might play a role in the development of diabetes complications. Moreover, the variability of each risk factor, when contemporarily present, may have additive effects. However, the question is whether variability is causal or a marker. Evidence shows that the quality of care and the attainment of the target impact on the variability of all risk factors. On the other hand, for some of them causality may be considered. Although specific studies are still lacking, it should be useful checking the variability of a risk factor, together with its magnitude out of the normal range, in clinical practice. This can lead to an improvement of the quality of care, which, in turn, could further hesitate in an improvement of risk factors variability.

【 授权许可】

CC BY