Association of glucose and blood pressure variability on oxidative stress in patients with type 2 diabetes mellitus and hypertension: a cross-sectional study

Diabetology & Metabolic Syndrome

Munenori Hiromura¹  Masakazu Koshibu¹  Hiroya Gima¹  Tomoyasu Fukui¹  Yusaku Mori¹  Makoto Ohara¹  Hiroe Nagaike¹  Takeshi Yamamoto¹  Toshiyuki Hayashi¹  Tsutomu Hirano¹  Yo Kohata¹ 

[1]Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine

关键词: Glucose variability;    Blood pressure variability;    Continuous glucose monitoring;    Ambulatory blood pressure monitoring;    Oxidative stress;    Type 2 diabetes mellitus;   

DOI  :  10.1186/s13098-019-0425-y

来源: DOAJ

【 摘 要 】

Abstract Background The present study evaluated the effects of glucose and blood pressure (BP) variability on oxidative stress in patients with type 2 diabetes mellitus (T2DM) and hypertension. Methods A total of 60 inpatients with T2DM underwent continuous glucose monitoring (CGM) and ambulatory BP monitoring (ABPM). Oxidative stress was estimated using the diacron-reactive oxygen metabolites (d-ROMs) test. Glucose variability, mean glucose level, percentage coefficient of variation for glucose, mean amplitude of glycemic excursions (MAGE), and area under the postprandial plasma glucose curve were determined through CGM. BP variability was assessed by measuring average BP, standard deviation (SD) of systolic and diastolic BP, and coefficient of variation (CV) of systolic and diastolic BP during daytime and nighttime ABPM. Results Participants had a mean age of 64.5 ± 13.3 years with the duration of the disease 13.9 ± 12.4 years and HbA1c of 8.5 ± 1.2%. Univariate analysis showed that MAGE, nighttime SDs of systolic and diastolic BP, and nighttime CV of systolic BP were significantly correlated with d-ROMs. Further, stepwise multiple regression analysis identified MAGE, nighttime SD and CV of diastolic BP, estimated glomerular filtration rate, and smoking as independent contributors to d-ROMs. Conclusions Oxidative stress was associated with daily glucose and nighttime diastolic BP variability in patients with T2DM and hypertension. Trial registration UMIN Clinical Trial Registry UMIN000035615, Registered January 22, 2019—retrospectively registered

【 授权许可】

Unknown