Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease

BMC Cardiovascular Disorders

Elitza Markova-Car¹  Marta Žuvić¹  Leon Cindrić¹  Viktor Peršić²  Rajko Miškulin²  Damir Raljević²  Sandra Kraljević Pavelić³ 

[1] Department of Biotechnology, University of Rijeka, Radmile Matejčić 2, 51000, Rijeka, Croatia;Department of Medical Rehabilitation, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000, Rijeka, Croatia;Division of Cardiology, Hospital for Medical Rehabilitation of the Heart and Lung Diseases and Rheumatism “Thalassotherapia Opatija”, M. Tita 188, 51410, Opatija, Croatia;Faculty of Health Studies, University of Rijeka, Viktora Cara Emina 5, 51000, Rijeka, Croatia;

关键词: Vitamin D receptor gene polymorphisms;    BsmI;    Taq1;    Myocardial infarction;    Coronary artery disease;    RT-PCR;   

DOI  :  10.1186/s12872-021-01959-x

来源: Springer

【 摘 要 】

BackgroundVitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD). As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Therefore, the objective of this study was to analyze three well-studied VDR gene polymorphisms—Fok1 (rs2228570), BsmI (rs1544410) and Taq1 (rs731236)—in a cohort of CAD patients after acute myocardial infarction.MethodsIn the presented cross-sectional study, 155 participants with CAD after acute myocardial infarction and 104 participants in a control group without CAD were enrolled. The participants in both groups were Caucasians of European origin. The genotyping of VDR polymorphisms rs2228570, rs1544410 and rs731236 was assessed by RT-PCR.ResultsThe results show an association between the T/T genotype of the BsmI (rs1544410) and the G/G genotype of the Taq1 (rs731236) VDR polymorphism and CAD patients after acute myocardial infarction. There was no association between the Fok1 (rs2228570) VDR polymorphism and CAD patients after acute myocardial infarction.ConclusionThe presented results suggest a potential association of the BsmI (rs1544410) and Taq1 (rs731236) VDR polymorphisms with CAD patients after myocardial infarction.

【 授权许可】

CC BY