Vitamin D receptor gene polymorphisms and Parkinson's disease in a population with high ultraviolet radiation exposure

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:352

Article

Gatto, Nicole M.¹  Sinsheimer, Janet S.^5,6,7  Cockburn, Myles⁸  Escobedo, Loraine A.⁸  Bordelon, Yvette⁴  Ritz, Beate^2,3,4 

[1] Loma Linda Univ, Sch Publ Hlth, Ctr Nutr Hlth Lifestyles & Dis Prevent, Loma Linda, CA 92350 USA

[2] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Dept Environm Hlth Sci, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90024 USA

[6] Univ Calif Los Angeles, Dept Biomath, Los Angeles, CA 90024 USA

[7] Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA 90024 USA

[8] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA

关键词: Vitamin D;    Ultraviolet radiation;    Parldnson's disease;    Vitamin D receptor gene polymorphisms;    TaqI;    ApaI;   

DOI  :  10.1016/j.jns.2015.03.043

来源: Elsevier

【 摘 要 】

Introduction: A high prevalence of vitamin D deficiency has been reported in Parkinson's disease (PD). Epidemiologic studies examining variability in genes involved in vitamin D metabolism have not taken into account level of exposure to ultraviolet radiation (UVR). We examined whether exposure to UVR (as a surrogate for vitamin D levels) and variations in the vitamin D receptor gene (VDR) are associated with PD. Methods: Within a geographical information system (GIS) we linked participants' geocoded residential address data to ground level UV data to estimate historical exposure to UVR. Six SNPs in VDR were genotyped in non-Hispanic Caucasian subjects. Results: Average lifetime UVR exposure levels were >5000 Wh/m(2), which was higher than levels for populations in previous studies, and UVR exposure did not differ between cases and controls. Homozygotes for the rs731236 TT (major allele) genotype had a 31% lower risk of PD risk (OR = 0.69; 95% CI = 0.49,0.98: p = 0.04 for TT vs. TC + CC). The rs7975232 GG (minor allele) genotype was also associated with decreased risk of PD (OR = 0.63; 95% CI = 0.42,0.93; p = 0.02 for GG vs. TG + TT). The association between PD risk and a third locus, rs1544410 (BsmI), was not statistically significant after adjustment for covariates, although there was a trend for lower risk with the GG genotype. Conclusions: This study provides initial evidence that VDR polymorphisms may modulate risk of PD in a population highly exposed to UVR throughout lifetime. (C) 2015 Published by Elsevier B.V.

【 授权许可】

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