Incidence and risk factors of retinopathy of prematurity in an Italian cohort of preterm infants

Italian Journal of Pediatrics

Domenico Lepore¹  Caterina Coviello²  Fiorenza Panin²  Carlo Dani³  Simonetta Costa⁴  Giovanni Vento⁴  Velia Purcaro⁴  Saverio Frosini⁵ 

[1] Department of Ophthalmology, Gemelli Foundation IRCSS, Catholic University of the Sacred Heart, Rome, Italy;Division of Neonatology, Careggi University Hospital, Largo Brambilla 3, 50141, Florence, Italy;Division of Neonatology, Careggi University Hospital, Largo Brambilla 3, 50141, Florence, Italy;Department of Neurosciences, Psychology, Drug Research and Child Health, Careggi University Hospital of Florence, Florence, Italy;Division of Neonatology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of Sacred Heart, Rome, Italy;Eye Clinic, Neuromuscular and Sense Organs Department, Careggi University Hospital, Florence, Italy;

关键词: Retinopathy of prematurity;    Risk factors;    Human milk;    Interventricular hemorrhage;    Preterm infants;   

DOI  :  10.1186/s13052-021-01011-w

来源: Springer

【 摘 要 】

ObjectiveNon-negligible differences in retinopathy of prematurity (ROP) and its risk factors between different neonatal intensive care units (NICUs) are reported. Our aim was to assess the incidence and risk factors for ROP development in a large cohort of very preterm infants who were assisted in two Italian NICUs.MethodsPreterm infants with gestational age between 23+ 0 and 29+ 6 weeks were stratified into subgroups of infants who developed ROP and those who did not; their clinical characteristics were compared with univariate and multivariable logistic regression analyses.ResultsWe studied a total of 178 infants of whom 67 (38%) developed ROP (stage 1: n = 12; stage 2: n = 41; stage 3: n = 14). Regression analysis demonstrated that maternal milk (OR 0.979, 95% Cl 0.961–0.998) decreased the risk of developing ROP, while intraventricular hemorrhage (IVH) (OR 2.055, 95% Cl 1.120–3.772) increased it. Moreover, maternal milk was found to decrease (OR 0.981, 95% Cl 0.964–0.997) the risk of ROP at discharge, while RBC transfusion increased it (OR 1.522, 95% Cl 1.208–1.916).ConclusionsIn our cohort the occurrence of ROP was similar to that previously reported. Strategies for promoting the use of mother’s own milk, preventing IVH, and standardizing the approach to RBC transfusions could contribute to decreasing the risk of ROP in very preterm infants.

【 授权许可】

CC BY