Risk factors for lymph node metastasis in gastric neuroendocrine tumor: a retrospective study

BMC Surgery

Shichao Ai¹  Xiaofeng Lu¹  Wenxian Guan¹  Song Liu¹  Meng Wang¹  Xianghui Li¹  Lihua Shao¹  Feng Sun¹  Zhengyang Yang² 

[1] Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan RD, 210008, Nanjing, China;Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, 100050, Beijing, China;

关键词: Gastric neuroendocrine tumor;    Lymph node metastasis;    Risk factors;   

DOI  :  10.1186/s12893-021-01174-7

来源: Springer

【 摘 要 】

BackgroundLymph node metastasis (LNM) plays a vital role in the determination of clinical outcomes in patients with gastric neuroendocrine tumor (G-NET). Preoperative identification of LNM is helpful for intraoperative lymphadenectomy. This study aims to investigate risk factors for LNM in patients with G-NET.MethodsWe performed a retrospective study involving 37 patients in non-LNM group and 82 patients in LNM group. Data of demographics, preoperative lab results, clinical–pathological results, surgical management, and postoperative situation were compared between groups. Significant parameters were subsequently entered into logistic regression for further analysis.ResultsPatients in LNM group exhibited older age (p = 0.011), lower preoperative albumin (ALB) (p = 0.003), higher carcinoembryonic antigen (CEA) (p = 0.020), higher International normalized ratio (p = 0.034), longer thrombin time (p = 0.018), different tumor location (p = 0.005), higher chromogranin A positive rate (p = 0.045), and higher Ki-67 expression level (p = 0.002). Logistic regression revealed ALB (p = 0.043), CEA (p = 0.032), tumor location (p = 0.013) and Ki-67 (p = 0.041) were independent risk factors for LNM in G-NET patients.ConclusionsALB, CEA, tumor location, and Ki-67 expression level correlate with the risk of LNM in patients with G-NET.

【 授权许可】

CC BY