Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania

BMC Surgery

Research Article

Martynas Luksta¹  Rimantas Bausys²  Augustinas Bausys²  Eugenijus Stratilatovas²  Dalius Klimas³  Kazimieras Maneikis³  Kestutis Strupas⁴  Indre Vysniauskaite⁵ 

[1] Center of Abdominal surgery, Vilnius University Hospital Santaros Klinikos, Santariskiu str. 2, 08661, Washington, USA;Department of Abdominal Surgery and Oncology, National Cancer Institute, Santariskiu str. 1, 08660, Vilnius, Lithuania;Faculty of Medicine, Vilnius University, Ciurlionio str. 21, 03101, Vilnius, Lithuania;Faculty of Medicine, Vilnius University, Ciurlionio str. 21, 03101, Vilnius, Lithuania;Faculty of Medicine, Vilnius University, Ciurlionio str. 21, 03101, Vilnius, Lithuania;Center of Abdominal surgery, Vilnius University Hospital Santaros Klinikos, Santariskiu str. 2, 08661, Washington, USA;School of Medicine, Georgetown University, Washington, D.C., USA;

关键词: Early gastric cancer;    Lymph node metastasis;    Risk factors;    Mucosal tumor;    T1a;   

DOI  :  10.1186/s12893-017-0304-0

 received in 2017-07-02, accepted in 2017-11-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCurrent risk factors for lymph node metastasis in early gastric cancer have been primarily determined in Asian countries; however their applicability to Western nations is under discussion. The aim of our study was to identify risk factors associated with lymph node metastasis in Western cohort patients from the Eastern European country - Lithuania.MethodsA total of 218 patients who underwent open gastrectomy for early gastric cancer were included in this retrospective study. After histolopathological examination, risk factors for lymph node metastasis were evaluated. Overall survival was evaluated and factors associated with long-term outcomes were analyzed.ResultsLymph node metastases were present in 19.7% of early gastric cancer cases. The rates were 5/99 (4.95%) for pT1a tumors and 38/119 (31.9%) for pT1b tumors. Submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation were identified as independent risk factors for lymph node metastasis. Submucosal tumor invasion and lymphovascular invasion were also associated with worse 5-year survival results.ConclusionOur study established submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation as risk factors for lymph node metastasis.

【 授权许可】

CC BY   
© The Author(s). 2017