Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort

Cardiovascular Diabetology

Cesar I. Fernandez-Lazaro¹  María J. Guembe²  Conchi Moreno-Iribas³  Estefanía Toledo⁴  Carmen Sayon-Orea⁵ 

[1] Department of Health, Government of Navarre, Vascular Risk in Navarre Investigation Group, Pamplona, Spain;Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, C/Irunlarrea 1, 31008, Pamplona, Spain;IdiSNA, Navarra Institute for Health Research, Pamplona, Spain;Navarrabiomed-Miguel Servet Foundation, Pamplona, Spain;Department of Health, Government of Navarre, Vascular Risk in Navarre Investigation Group, Pamplona, Spain;Dirección General de Salud del Gobierno de Navarra, Servicio de Planificación, Evaluación Y Gestión del Conocimiento, Pamplona, Spain;Department of Health, Government of Navarre, Vascular Risk in Navarre Investigation Group, Pamplona, Spain;IdiSNA, Navarra Institute for Health Research, Pamplona, Spain;Health Services Research on Chronic Patients Network (REDISSEC), Instituto de Salud Carlos III, Madrid, Spain;Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, C/Irunlarrea 1, 31008, Pamplona, Spain;IdiSNA, Navarra Institute for Health Research, Pamplona, Spain;Centro de Investigación Biomédica en Red Área de Fisiología de la Obesidad y la Nutrición (CIBEROBN), Madrid, Spain;Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, C/Irunlarrea 1, 31008, Pamplona, Spain;IdiSNA, Navarra Institute for Health Research, Pamplona, Spain;Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain;

关键词: Cardiovascular disease;    Metabolic syndrome;    Myocardial infarction;    Stroke;    Cardiovascular mortality;    Mediterranean cohort;    Cohort study;   

DOI  :  10.1186/s12933-020-01166-6

来源: Springer

【 摘 要 】

BackgroundWe aimed to investigate the association of metabolic syndrome (MetS) and its single components with cardiovascular risk and estimated their impact on the prematurity of occurrence of cardiovascular events using rate advancement periods (RAPs).MethodsWe performed prospective analyses among 3976 participants (age range: 35–84, 55% female) in the Vascular Risk in Navarre (RIVANA) Study, a Mediterranean population-based cohort. MetS was defined based on the modified criteria of the American Heart Association/National Heart, Lung, and Blood Institute and the International Diabetes Federation. The primary endpoint was major cardiovascular event (a composite of myocardial infarction, stroke, or mortality from cardiovascular causes). Secondary endpoints were incidence of non-fatal myocardial infarction and non-fatal stroke, cardiovascular mortality, and all-cause mortality. Cox proportional hazards models, adjusted for potential confounders, were fitted to evaluate the association between MetS and its single components at baseline with primary and secondary endpoints.ResultsDuring a median follow-up of 12.8 years (interquartile range, 12.5–13.1), we identified 228 primary endpoint events. MetS was associated with higher risk of incidence of major cardiovascular event, cardiovascular and all-cause mortality, but was neither associated with higher risk of myocardial infarction nor stroke. Compared with participants without MetS, the multivariable hazard ratio (95% confidence interval [CI]) among participants with MetS was 1.32 (1.01–1.74) with RAP (95% CI) of 3.23 years (0.03, 6.42) for major cardiovascular event, 1.64 (1.03–2.60) with RAP of 3.73 years (0.02, 7.45) for cardiovascular mortality, and 1.45 (1.17–1.80) with RAP of 3.24 years (1.21, 5.27) for all-cause mortality. The magnitude of the associations of the single components of MetS was similar than the predicted by MetS. Additionally, for each additional trait of MetS, incidence of major cardiovascular event relatively increased by 22% (1.22, 95% CI 1.09–1.36) with RAP of 2.31 years (0.88, 3.74).ConclusionsMetS was independently associated with CVD risk, cardiovascular and all-cause mortality. Components of the MetS were associated with similar magnitude of increased CVD, which suggests that MetS was not in excess of the level explained by the presence of its single components. Further research should explore the association of different combinations of the components of MetS with CVD.

【 授权许可】

CC BY