Collagen production and niche engineering: A novel strategy for cancer cells to survive acidosis in DCIS and evolve

Evolutionary Applications

Tingan Chen¹  Joseph Johnson¹  Alexander D. Borowsky²  Hidetoshi Mori²  Andriy Marusyk³  Robert J. Gillies³  Liping Xu³  Samantha Byrne³  Mehdi Damaghi⁴  Nathan D. Gallant⁵ 

[1] Analytic Microscopy Core, Moffitt Cancer Center and Research Institute, Tampa, FL, USA;Center for Immunology and Infectious Diseases, Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA;Department of Cancer Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA;Department of Cancer Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA;Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Tampa, FL, USA;Department of Mechanical Engineering, University of South Florida, Tampa, FL, USA;

关键词: anoikis;    cancer evolution;    collagen production;    extracellular matrix remodeling enzymes;    K‐RAS;    Niche construction and engineering;    SMAD;    tumor microenvironment;   

DOI  :  10.1111/eva.13075

来源: Wiley

【 授权许可】

CC BY