Histological comparison of malignant epithelioid mesothelioma in young and adult cattle

The Journal of Veterinary Medical Science

article

Yuuto KAWASHIMA¹  Ayako FUJIMOTO²  Morihiro SAITO³  Osamu MIKAMI⁴  Yoshiharu ISHIKAWA⁴  Koichi KADOTA⁴ 

[1] Sorachi Livestock Hygiene Service Center;Hidaka Livestock Hygiene Service Center;College of Nutritional Science, Kagawa Nutrition University;Hokkaido Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization

关键词: cattle;    collagen production;    cytokeratin 7;    epithelioid mesothelioma;    pleomorphic mesothelioma;   

DOI  :  10.1292/jvms.20-0467

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

The histology and immunohistochemistry of pleomorphic and conventional epithelioid mesotheliomas were examined. The former was detected in two young calves aged 2 and 4 months and was characterized by pleomorphic and atypical cells with decreased expression of cytokeratin 7 (CK7). In contrast, the latter was found in a 31-month-old heifer, consisting of tumor cells uniform in size and shape with CK7 expression in nearly all cells. Production of collagen by tumor cells was demonstrated in both histological types, and was considered to be characteristic of bovine epithelioid mesothelioma. Pleomorphic mesothelioma is far more pleomorphic and mitotically active than conventional mesothelioma, and its normal counterpart may be immature mesothelial cells with high proliferation potential, which exist in fetal life and early calfhood.

【 授权许可】

Unknown