Cytotoxicity Assay From Fractions of Hedyotis corymbosa Extract Against Breast Cancer Cell Line T47D

ISCC (Indonesian Journal of Cancer Chemoprevention)

ARTICLE

Rina Andriyani¹  Chandra Risdian¹  Zalinar Udin¹ 

[1] Research Center for Chemistry, Indonesian Institute of Sciences

关键词: breast cancer;    herbal medicine;    T47D;    Hedyotis corymbosaFull TextPDF ReferencesAhmad;    R.;    Ali;    A.M.;    Israf;    D.A.;    Ismail;    N.H.;    Saari;    K. and Lajis;    N.H.;    2004;    Antioxidant;    Radical Scavenging;    Anti-Inflamatory;    Cytotoxic And Antibacterial Activities Of Methanolic Extracts Of Some Hedyotis Species;    Life Sci .;    76 (17);    1953-1964. CrossRef;   

DOI  :  10.14499/indonesianjcanchemoprev2iss1pp182-186

学科分类：药学

来源: Indonesian Society for Cancer Chemoprevention

【 摘 要 】

Drug discovery for cancer medication is the most important effort that researcher do at this time. Indonesia bio diversities have possibility as a cancer medicine sources. Finding a herbal medicine for cancer treatment is a first step to find a right cancer medicine in the future. This research has already completed for the earlier another research. Some fractions of Hedyotis corymbosa extract has been analyzed using Sulforhodamine B method with UV wavelength 515 nm against T47D cell line, a human breast cancer. There are Hexane extract, Methylene chloride extract and Ethyl acetate extract, and give inhibitory concentration 50 (IC 50 )  of 33.45 µg/ml, 54.59 µg/ml and 52.58 µg/ml, respectively. Ethanolic extract, itself has IC 50 of 61.57 µg/ml, whereas IC 50 value of Cisplatinum is  9.63 µg/ml. There is a difference between the ethanolic extracts with the other fraction.

【 授权许可】

CC BY-NC