The Clinical Efficacy and Safety of Four-Weekly Docetaxel as First-Line Therapy in Elderly Lung Cancer Patients with Squamous Cell Carcinoma

Tuberculosis and Respiratory Diseases

article

Jong Hyun Choi¹  Juwhan Choi¹  Sang Mi Chung¹  Jee Youn Oh¹  Young Seok Lee¹  Kyung Hoon Min¹  Gyu Young Hur¹  Jae Jeong Shim¹  Kyung Ho Kang¹  Hyun Kyung Lee²  Sung Yong Lee¹ 

[1] Department of Internal Medicine, Korea University Guro Hospital;Department of Internal Medicine, Inje University Busan Paik Hospital

关键词: Carcinoma;    Non-Small-Cell Lung;    Chemotherapy;    Docetaxel;    Treatment Outcome;    Safety;    Therapeutics;    Aged;    Lung Neoplasms;    Carcinoma;    Squamous Cell;   

DOI  :  10.4046/trd.2018.0019

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Background Docetaxel is one of the standard treatments for advanced non-small cell lung cancer. Docetaxel is usually administered in a 3-week schedule, but there is significant toxicity. In this phase II clinical study, we investigated the efficacy and safety of a 4-weekly schedule of docetaxel monotherapy, as first-line chemotherapy for advanced squamous cell carcinoma in elderly lung cancer patients. Methods Patients with stage IIIB/ IV lung squamous-cell carcinoma age 70 or older, that had not undergone cytotoxic chemotherapy were enrolled. Patients received docetaxel 25 mg/m 2 on days 1, 8, and 15, every 4 weeks. Primary endpoint was the objective response rate (ORR). Secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity profiles. Results A total of 19 patients were enrolled. Among 19 patients, 17 were for evaluated efficacy and safety. In the intent-to-treat population, ORR and disease control rate (DCR) were 11.8% and 47.1%, respectively. In the response evaluable population, ORR was 16.7% and DCR was 66.7%. Median PFS and OS were 3.1 months and 3.3 months, respectively. There were three adverse grade 3/4 events. Grade 1 neutropenia was reported in one patient. Conclusion Our data failed to demonstrate efficacy of a 4-weekly docetaxel regimen, in elderly patients with a poor performance status. However, incidence of side effects, including neutropenia, was lower than with a 3-week docetaxel regimen, as previously reported.

【 授权许可】

CC BY-NC