Serial Changes in Mannose-Binding Lectin in Patients with Sepsis

Tuberculosis and Respiratory Diseases

article

Jin Won Huh¹  Kyuyoung Song²  Hwa Jung Kim³  Jung-Sun Yum⁴  Sang-Bum Hong¹  Chae-Man Lim¹  Younsuck Koh¹ 

[1] Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine;Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine;Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine;R&D Center, CHA Vaccine Institute

关键词: Mannose-Binding Lectin;    Cytokines;    Shock;    Septic;    Prognosis;   

DOI  :  10.4046/trd.2017.0060

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Background Mannose-binding lectin (MBL) deficiency leads to increased susceptibility to infection. We investigated whether serial changes in MBL levels are associated with the prognosis of patients diagnosed with septic shock, and correlated with cytokine levels. Methods We enrolled 131 patients with septic shock in the study. We analyzed the serum samples for MBL and cytokine levels at baseline and 7 days later. Samples on day 7 were available in 73 patients. Results We divided the patients with septic shock into four groups according to serum MBL levels (<1.3 µg/mL or ≥1.3 µg/mL) on days 1 and 7. Patients with low MBL levels on day 1 and high MBL levels on day 7 showed a favorable prognosis for 28-day survival (odds ratio, 1.96, 95% confidence interval, 1.10-2.87; p=0.087). The high MBL group on day 7 showed a significant decrease in monocyte chemoattractant protein 1, interleukin (IL)-1β, IL-6, IL-8, interferon-γ, and granulocyte macrophage colony-stimulating factor levels compared with the low MBL group on day 7. Conclusion The increase in MBL levels of patients with septic shock may suggest a favorable prognosis and attenuate pro-inflammatory and anti-inflammatory responses.

【 授权许可】

CC BY-NC