Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples

Tuberculosis and Respiratory Diseases

article

Yousang Ko¹  Jeong Hwan Shin²  Hyun-Kyung Lee³  Young Seok Lee⁴  Suh-Young Lee¹  So Young Park¹  Eun-Kyung Mo¹  Changhwan Kim⁵  Yong Bum Park¹ 

[1] Division of Pulmonary, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine;Department of Laboratory Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine;Division of Pulmonary, Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine;Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital;Department of Internal Medicine, Jeju National University Hospital

关键词: Tuberculosis;    Pulmonary;    Mycobacterium tuberculosis;    Infectious Disease Incubation Period;    Induced Sputum;   

DOI  :  10.4046/trd.2017.80.1.27

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Background A sputum culture is the most reliable indicator of the infectiousness of pulmonary tuberculosis (PTB); however, a spontaneous sputum specimen may not be suitable. The aim of this study was to evaluate the infectious period in patients with non-drug-resistant (DR) PTB receiving adequate standard chemotherapy, using induced sputum (IS) specimens. Methods We evaluated the duration of infectiousness of PTB using a retrospective cohort design. Results Among the 35 patients with PTB, 22 were smear-positive. The rates of IS culture positivity from baseline to the sixth week of anti-tuberculosis medication in the smear-positive PTB group were 100%, 100%, 91%, 73%, 36%, and 18%, respectively. For smear-positive PTB cases, the median time of conversion to culture negativity was 35.0 days (range, 28.0-42.0 days). In the smear-negative PTB group (n=13), the weekly rates of positive IS culture were 100%, 77%, 39%, 8%, 0%, and 0%, respectively, and the median time to conversion to culture-negative was 21.0 days (range, 17.5-28.0 days). Conclusion The infectiousness of PTB, under adequate therapy, may persist longer than previously reported, even in patients with non-DR PTB.

【 授权许可】

CC BY-NC