Association of Ambient air Pollution with risk of preeclampsia during pregnancy: a retrospective cohort study

BMC Public Health

Huiqing Hou¹  Guangli Guo¹  Lu Jia¹  Ting Zhang¹  Li Wang¹  Songli Fan²  Qing Liu³ 

[1] Department of Obstetrics and Gynecology, Hebei General Hospital, Hebei Medical University, No. 348 Heping Road, 050051, Shijiazhuang, Hebei, China;Hebei Women and Children’s Health Center, No. 147, Jianhua Street, 050000, Shijiazhuang, China;Zibo Maternal and Child Health Hospital, No. 66, North Tianjin Road, 255000, Zibo, Shandong, China;

关键词: Preeclampsia;    Air pollution;    PM;    PM;    NO;    SO;    CO;    O;    Epidemiology;    China;   

DOI  :  10.1186/s12889-020-09719-w

来源: Springer

【 摘 要 】

BackgroundAmbient air pollution is becoming a serious environmental problem in China. The results were inconsistent on that air pollution was a risk factor of preeclampsia in pregnancy.MethodsTotal 116,042 pregnant women were enrolled from 22 hospitals in 10 cities of Hebei Province, China from January 1, 2015 to December 31, 2017. The parturients were divided into preeclampsia group (PE group) and non-preeclampsia group (non-PE group). The data of air pollutants, namely, particulate matter (PM)2.5, PM10, NO2, SO2, CO, O3 were collected from China Environmental Inspection Station.ResultsAmong the 116,042 pregnant women, 2988 (2.57%) pregnant women were diagnosed with preeclampsia. The concentrations of exposed PM2.5, PM10, NO2 and O3 in the PE group were significantly higher than those in the non-PE group, and they were risk factors of the PE group in the first and second trimester of pregnancy respectively. The concentrations of exposed SO2 and CO in PE patients and non-PE women were not different, but high concentration of these air pollutants were risk factors to PE in the second trimester.ConclusionThe exposure to PM2.5, PM10, NO2, O3 were risk factors for preeclampsia in the first and second trimester of pregnancy, while only at high level, SO2 and CO were risk factors for preeclampsia in the second trimester of pregnancy.

【 授权许可】

CC BY