Anti-dyslipidemic properties of green gold nanoparticle: improvement in oxidative antioxidative balance and associated atherogenicity and insulin resistance

Clinical Phytoscience

Mina Hemmati¹  Mehran Hosseini²  Moones Honarmand³  Reyhane Javanshir⁴ 

[1] Biochemistry Department, Faculty of Medicine, Zanjan University of Medical sciences, 4513956111, Zanjan, Iran;Biochemistry Department, Faculty of Medicine, Birjand University of Medical Sciences, 9717853577, Birjand, Iran;Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, 9717853577, Birjand, Iran;Department of Chemical Engineering, Birjand University of Technology, Birjand, Iran;Student Research Committee, Birjand University of Medical Sciences, 9717853577, Birjand, Iran;

关键词: Diabetes mellitus;    Ziziphus jujube;    AuNPs;    Prooxidant antioxidant balance;    Oxidant/antioxidant status;   

DOI  :  10.1186/s40816-020-00224-6

来源: Springer

【 摘 要 】

BackgroundNowadays, the green synthesis of AuNPs in the presence of plants has been attracted a lot of attention. Herein, in vivo antidiabetic activity of AuNPs synthesized using Ziziphus jujuba in streptozotocin-induced diabetic rats has been evaluated.MethodsFormation of AuNPs was confirmed by UV-vis, HR-TEM and XRD. Different doses of jujube gold nanoparticles (0.5 and 1 mg/kg) were used to treat streptozotocin-induced diabetic rats in different groups. At the end of experiment (21 days), serum level of fasting blood glucose (FBG), insulin, Body weight, HOMA-IR, vitamin D, ALT, AST, urea, creatinine, lipid profile, prooxidant-antioxidant balance (PAB) and liver oxidative stress markers were determined.Resultsresults showed a significant decrease in the level of liver MDA (P = 0.001), fasting blood glucose (P = 0.0001), HOMA-IR (P = 0.0001), ALT (P = 0.0001), AST (P = 0.0001), urea (P = 0.02), Triglycerides (P = 0.002), Total cholesterol (P = 0.0001), PAB (P = 0.0001) and AIP (P = 0.001) and in contrast a significant increase total antioxidant capacity (P = 0.02), insulin (P = 0.03), Body weight (P = 0.0001) and vitamin D (P = 0.0001) in the AuNPs-treated diabetic group compared to the diabetic rats. No significant change was observed in the total thiol group (P = 0.18), LDL-C (P = 0.43), creatinine (P = 0.09) and HDL-C (P = 0.71) level in diabetic rats treated with AuNPs compared to diabetic rats.ConclusionThe results of this study proves that green AuNPs exerted promising antidiabetic and anti-oxidant properties.

【 授权许可】

CC BY