Methods for quantification of cannabinoids: a narrative review

Journal of Cannabis Research

Ali Seyfoddin¹  Masoumeh Pourseyed Lazarjani¹  Stephanie Torres²  Owen Young³  Thom Hooker⁴  Chris Fowlie⁴ 

[1] Drug Delivery Research Group, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand;Drug Delivery Research Group, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand;Chapman University, Orange, California, USA;School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand;ZeaCann LTD, Auckland, New Zealand;

关键词: Cannabis;    Cannabinoids;    Analytical;    THC;    CBD;    Quantification;   

DOI  :  10.1186/s42238-020-00040-2

来源: Springer

【 摘 要 】

BackgroundAround 144 cannabinoids have been identified in cannabis plant, among them tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most prominent ones. Because of the legal restrictions on cannabis in many countries, it is difficult to obtain standards to use in research; nonetheless, it is important to develop a cannabinoid quantification technique with pharmaceutical applications for quality control of future therapeutic cannabinoids.MethodTo find relevant articles for this narrative review paper, a combination of keywords such as medicinal cannabis, analytical, quantification and cannabinoids were searched for in PubMed, EMBASE, MEDLINE, Google Scholar and Cochrane Library (Wiley) databases.ResultsThe most common cannabinoid quantification techniques include gas chromatography (GC) and high-performance liquid chromatography (HPLC). GC is often used in conjunction with mass spectrometry (MS) or flame ionization detection (FID). The major advantage of GC is terpenes quantification however, for evaluating acidic cannabinoids it needs to be derivatised. The main advantage of HPLC is the ability to quantify both acidic and neutral forms of cannabinoids without derivatisation which is often with MS or ultraviolet (UV) detectors.ConclusionBased on the information presented in this review, the ideal cannabinoid quantification method is HPLC- MS/MS for the cannabinoids.

【 授权许可】

CC BY