Mechanisms contributing to cognitive deficits in cannabis users

NEUROPHARMACOLOGY

卷:124

Review

Mizrahi, Romina^1,2,3  Watts, Jeremy J.^2,3  Tseng, Kuei Y.⁴ 

[1] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada

[2] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

[3] PET Ctr, CAMH, Res Imaging Ctr, Toronto, ON, Canada

[4] Rosalind Franklin Univ, Chicago Med Sch, Dept Cellular & Mol Pharmacol, N Chicago, IL 60064 USA

关键词: Cognition;    Prefrontal cortex;    Cannabis;    Cannabinoids;    Imaging;    Connectivity;    CB1 receptors;    THC;   

DOI  :  10.1016/j.neuropharm.2017.04.018

来源: Elsevier

【 摘 要 】

Studies from preclinical animal models indicate that sustained activation of CB1 receptor signaling is a major contributing factor for the onset of cognitive deficits associated to chronic cannabis use, in particular within the working memory and decision-making domains. Yet, very few studies have been designed to directly assess the role of CB1 receptors in mediating the effects of cannabis on human brain function. This perspective review article provides an overview of current state of knowledge on possible neurobiological mechanisms accounting for the detrimental effects of chronic cannabis use on cognition and related changes in brain structure and functional connectivity. This article is part of the Special Issue entitled A New Dawn in Cannabinoid Neurobiology. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free