Investigation of reactive astrogliosis effect on post-stroke cognitive impairment

Journal of Neuroinflammation

Chien-Hung Chang¹  Yeu-Jhy Chang¹  Tsong-Hai Lee¹  Ting-Yu Chang¹  Chi-Hung Liu¹  Kuo-Lun Huang¹  Meng-Yang Ho²  Jung-Lung Hsu³  Ing-Tsung Hsiao⁴  Shiaw-Pyng Wey⁴  Tzu-Chen Yen⁴  Kun-Ju Lin⁴  Kuan-Yi Wu⁵  Yi-Ming Wu⁶  Nobuyuki Okamura⁷ 

[1] Department of Neurology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan;Department of Neurology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan;Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan;Department of Neurology, New Taipei Municipal TuCheng Hospital, Chang Gung Memorial Hospital, Chang Gung University, New Taipei City, Taiwan;Taipei Medical University, College of Humanities and Social Sciences, Graduate Institute of Humanities in Medicine and Research Center for Brain and Consciousness, Shuang Ho Hospital, Taipei, Taiwan;Department of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan;Healthy Aging Research Center and Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan;Department of Psychiatry, Chang Gung Memorial Hospital, Taoyuan, Taiwan;Department of Radiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan;Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan;

关键词: Post-stroke cognitive impairment;    Reactive astrogliosis;    PET;    Stroke;   

DOI  :  10.1186/s12974-020-01985-0

来源: Springer

【 摘 要 】

BackgroundThe aim of this study is to investigate the associations between post-stroke cognitive impairment (PSCI) severity and reactive astrogliosis (RA) extent on normalized 18F-THK-5351 positron-emission tomography (PET) imaging in amyloid-negative patients with first-ever stroke.MethodsWe prospectively enrolled 63 amyloid-negative patients with first-ever stroke. Neurocognitive evaluation, MRI, 18F-THK-5351, and 18F-florbetapir PET were performed around 3 months after stroke. The 18F-THK-5351 uptake intensity was normalized using a signal distribution template to obtain the Z-SUM scores as the RA extent in the whole brain and cerebral hemisphere ipsilateral to stroke lesion. We evaluated stroke volume, leukoaraiosis, and brain atrophy on MRI. We used a comprehensive neurocognitive battery to obtain composite cognitive scores, and defined PSCI as a general cognitive function score < − 1. We analyzed the influence of Z-SUM scores on PSCI severity after adjusting for demographic, vascular, and neurodegenerative variables.ResultsTwenty-five of 63 stroke patients had PSCI. Patients with PSCI had older age, lower education, and more severe cortical atrophy and total Z-SUM scores. Total Z-SUM scores were significantly associated with general cognitive and executive functions at multiple regression models. Path analyses showed that stroke can exert cognitive influence directly by stroke itself as well as indirectly through RA, including total and ipsilateral Z-SUM scores, in patients with either right or left hemisphere stroke.ConclusionThe patterns and intensity of 18F-THK-5351 uptake in amyloid-negative patients with first-ever stroke were associated with PSCI manifestations, which suggests that RA presents a modulating effect in PSCI development.

【 授权许可】

CC BY