PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseases

NEUROSCIENCE LETTERS

卷:691

Review

Cai, Zhengxin¹  Li, Songye¹  Matuskey, David¹  Nabulsi, Nabeel¹  Huang, Yiyun¹ 

[1] Yale Univ, Dept Radiol & Biomed Imaging, PET Ctr, New Haven, CT 06520 USA

关键词: SV2A;    PET;    Synaptic density;    Alzheimer's disease;    Parkinson's disease;    Epilepsy;    Stroke;    Multiple sclerosis;    Huntington's disease;    Autism spectrum disorder;    Depression;    Schizophrenia;   

DOI  :  10.1016/j.neulet.2018.07.038

来源: Elsevier

【 摘 要 】

Synaptic vesicle glycoprotein 2A (SV2A) is expressed ubiquitously in neurons of the central nervous system, and is the binding target of the anti-epileptic drug levetiracetam. Because of the availability of positron emission tomography (PET) ligands targeting SV2A, there is increasing enthusiasm on the use of SV2A PET to study a variety of neuropsychiatric diseases. This review discusses the recent development of radioligands for PET imaging of SV2A and their potential use in the research and diagnosis of CNS diseases.

【 授权许可】

Free