Institute for Molecular Medicine Research Program

Phelps, Michael E

关键词: PET;    Molecular imaging probes;    Microfluidics;    In vitro molecular imaging;   

DOI  :  10.2172/1057390
RP-ID  :  DOE/ER/64249-1
PID  :  OSTI ID: 1057390

美国|英语

来源: SciTech Connect

【 摘 要 】

The objectives of the project are the development of new Positron Emission Tomography (PET) imaging instrumentation, chemistry technology platforms and new molecular imaging probes to examine the transformations from normal cellular and biological processes to those of disease in pre-clinical animal models. These technology platforms and imaging probes provide the means to: 1. Study the biology of disease using pre-clinical mouse models and cells. 2. Develop molecular imaging probes for imaging assays of proteins in pre-clinical models. 3. Develop imaging assays in pre-clinical models to provide to other scientists the means to guide and improve the processes for discovering new drugs. 4. Develop imaging assays in pre-clinical models for others to use in judging the impact of drugs on the biology of disease.