Serum adipocytokines and adiposity as predictive indices of preeclampsia

Clinical Hypertension

Ahmed Tijani Bawah¹  Huseini Alidu¹  Robert A. Ngala²  Francis Agyemang Yeboah²  Salifu Nanga³ 

[1] Department of Medical Laboratory Science, School of Allied Health Sciences, University of Health and Allied Health Sciences, PMB 31, Ho, Ghana;Department of Molecular Medicine, Kwame Nkrumah University Science and Technology, Kumasi, Ghana;School of Basic and Biomedical Science, University of Health and Allied Sciences, Ho, Ghana;

关键词: Preeclampsia;    Adiponectin;    Leptin;    Resistin;    Visfatin;   

DOI  :  10.1186/s40885-020-00152-0

来源: Springer

【 摘 要 】

BackgroundThis study was aimed at determining the levels of serum adiponectin, leptin, resistin, visfatin and lipids during the first trimester in pregnant women and to evaluate the relationship between these biochemical markers and preeclampsia (PE). Available evidence point to changes in the levels of these adipokines in PE hence this study examined the potential of using these biomarkers in the prediction of the disease.MethodsThis was a case-control study which compared first trimester serum biochemical and anthropometric parameters in pregnant women who subsequently developed PE and those who did not. Blood pressure and urine protein were determined after 20 weeks of gestation and diagnosis of PE performed according to the guidelines of the American Heart Association.ResultsThere was no significant difference (p > 0.05) in the lipid profile with the exception of HDL cholesterol which was significantly lower (p = 0.043) in the PE group compared to the normotensive group. There were, however, significant differences (p <  0.05) in the adipokines between the PE group and those without PE. Analyses of area under the receiver operating characteristic curves (AUCs) for the adipokines, showed their ability to correctly predict PE even after controlling for body mass index (BMI) and family history of hypertension.ConclusionAdiponectin, leptin, resistin and visfatin were found to be significant predictors of PE, with resistin being the best predictor after controlling for BMI. However, adiponectin was the best predictor after controlling for BMI, age, parity and family history of diabetes and preeclmapsia.

【 授权许可】

CC BY