Obesity and adipose tissue endocrine function

International Journal of Biomedical and Advance Research

Anuradha Rajiv Joshi

关键词: s Adipose tissue;    Adiponectin;    Leptin;    Resistin;   

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Many studies have profoundly changed the concept of adipose tissue from being an energy depot to an active endocrine organ. Adipose tissue secretes bioactive peptides, termed as ‘adipokines’.They act through autocrine, paracrine and endocrine pathways. In obesity, increased production of most adipokines affects multiple functions such as appetite and energy balance, immunity, insulin sensitivity, angiogenesis, blood pressure, lipid metabolism and haemostasis. Increased activity of the tumor necrosis factor and interleukin 6 are involved in the development of obesityrelated insulin resistance. Angiotensinogen has been implicated in hypertension and plasminogen activating inhibitor-1 in impaired fibrinolysis. Decreased levels of adiponectin indicate adipose tissue dysfunction in obesity. Thus increased adipose tissue mass plays a key role in the development of obesity-associated diseases and the development of obesity alters adipocyte-derived hormones or cytokines expression. This provides a link between obesity, impaired insulin sensitivity and metabolic defects in other tissues. The present review will focus on effect of obesity on adipose tissue endocrine function.

【 授权许可】

CC BY