Comparison of blood neoangiogenesis and lymphatic vascularization in colorectal adenomas from patients with and without concomitant colorectal cancer

Brazilian Journal of Medical and Biological Research

L.r. Moreira¹  A.a. Schenka¹  P. Latuf Filho¹  C.s.p. Lima¹  M.a.s. Trevisan¹  J. Vassallo¹ 

[1] ,Universidade Estadual de Campinas CIPED Laboratório de Patologia Investigativa e MolecularCampinas SP ,Brasil

关键词: Angiogenesis;    Colorectal adenoma;    Colorectal cancer;    Immunohistochemistry;    CD105;    D2-40;   

DOI  :  10.1590/S0100-879X2009005000004

来源: SciELO

【 摘 要 】

Blood and lymphatic vessel proliferation is essential for tumor growth and progression. Most colorectal carcinomas develop from adenomas (adenoma-carcinoma sequence) in a process due to accumulation of molecular genetic alterations. About 5% of adenomatous polyps are expected to become malignant, but data on the differential angiogenic patterns of these lesions in patients with and without concomitant cancer are missing. The aim of the present study is to compare the angiogenic and lymphatic patterns of adenomatous polyps from patients with and without sporadic cancer. Thirty adenomatous polyps (15 from patients with another principal malignant lesion, and 15 from patients without cancer) were submitted to immunohistochemical staining for CD105 (marker for neoangiogenesis) and D2-40 (marker for lymphatic endothelium). Microvessel density and total vascular area were determined by computer image analysis to quantify the immunostained and total areas, and to assess the number of microvessels. Adenomas from patients with carcinoma showed significantly higher values of total vascular area determined by immunostaining for CD105 (cutoff value = 4386 µm²; P = 0.019) and of lymphatic microvessel density determined by immunostaining with D2-40 (cutoff value = 11.5; P = 0.041) when compared with those from patients without cancer. The present data indicate a significant increase in blood microvascular area and in lymphatic microvascular counts in adenomas removed from patients with cancer.

【 授权许可】

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