期刊论文详细信息
Química Nova
In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)
Patricia Sartorelli2  Jefferson S. Santana2  Rafael C. Guadagnin2  João Henrique G. Lago2  Érika G. Pinto1  André G. Tempone1  Hélio A. Stefani1  Marisi G. Soares1  Adalberto M. Da Silva1 
[1] ,Universidade Federal de São Paulo Instituto de Ciências Ambientais, Químicas e Farmacêuticas Diadema SP ,Brasil
关键词: Schinus terebinthifolius Raddi;    Anacardiaceae;    trypanocidal activity;   
DOI  :  10.1590/S0100-40422012000400017
来源: SciELO
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【 摘 要 】

Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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