In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

Quimica nova

Tempone, André G.¹  Soares, Marisi G.²  Guadagnin, Rafael C.³  Santana, Jefferson S.³  Lago, João Henrique G.³  Sartorelli, Patricia³  Silva, Adalberto M. da⁴  Stefani, Hélio A.⁵  Pinto, Érika G.⁵ 

[1] Instituto Adolfo Lutz, São Paulo, Brasil;Universidade Federal de Alfenas, Alfenas, Brasil;Universidade Federal de São Paulo, Diadema, Brasil;Universidade Federal de Viçosa, Brasil;Universidade de São Paulo, São Paulo, Brasil

关键词: Schinus terebinthifolius Raddi;    Anacardiaceae;    trypanocidal activity.;   

DOI  :  10.1590/S0100-40422012000400017

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56µg/mL) when compared to benznidazole (IC50 43.14µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400µg/mL) while (-)-pinane showed an IC50 of 56.50µg/mL. The obtained results indicated that the epoxydation ofα-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.

【 授权许可】

CC BY