Quimica nova | |
In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae) | |
Tempone, André G.1  Soares, Marisi G.2  Guadagnin, Rafael C.3  Santana, Jefferson S.3  Lago, João Henrique G.3  Sartorelli, Patricia3  Silva, Adalberto M. da4  Stefani, Hélio A.5  Pinto, Érika G.5  | |
[1] Instituto Adolfo Lutz, São Paulo, Brasil;Universidade Federal de Alfenas, Alfenas, Brasil;Universidade Federal de São Paulo, Diadema, Brasil;Universidade Federal de Viçosa, Brasil;Universidade de São Paulo, São Paulo, Brasil | |
关键词: Schinus terebinthifolius Raddi; Anacardiaceae; trypanocidal activity.; | |
DOI : 10.1590/S0100-40422012000400017 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56µg/mL) when compared to benznidazole (IC50 43.14µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400µg/mL) while (-)-pinane showed an IC50 of 56.50µg/mL. The obtained results indicated that the epoxydation ofα-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.
【 授权许可】
CC BY
【 预 览 】
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