Química Nova | |
In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae) | |
Patricia Sartorelli2  Jefferson S. Santana2  Rafael C. Guadagnin2  João Henrique G. Lago2  Érika G. Pinto1  André G. Tempone1  Hélio A. Stefani1  Marisi G. Soares1  Adalberto M. Da Silva1  | |
[1] ,Universidade Federal de São Paulo Instituto de Ciências Ambientais, Químicas e Farmacêuticas Diadema SP ,Brasil | |
关键词: Schinus terebinthifolius Raddi; Anacardiaceae; trypanocidal activity; | |
DOI : 10.1590/S0100-40422012000400017 | |
来源: SciELO | |
【 摘 要 】
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202005130063890ZK.pdf | 307KB | download |