In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

Química Nova

Patricia Sartorelli²  Jefferson S. Santana²  Rafael C. Guadagnin²  João Henrique G. Lago²  Érika G. Pinto¹  André G. Tempone¹  Hélio A. Stefani¹  Marisi G. Soares¹  Adalberto M. Da Silva¹ 

[1] ,Universidade Federal de São Paulo Instituto de Ciências Ambientais, Químicas e Farmacêuticas Diadema SP ,Brasil

关键词: Schinus terebinthifolius Raddi;    Anacardiaceae;    trypanocidal activity;   

DOI  :  10.1590/S0100-40422012000400017

来源: SciELO

【 摘 要 】

Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.

【 授权许可】

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