期刊论文详细信息
Química Nova
In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)
Guadagnin, Rafael C.1  Soares, Marisi G.1  Tempone, André G.1  Santana, Jefferson S.1  Universidade Federal de Viçosa, Brasil1  Pinto, Érika G.1  Universidade Federal de São Paulo, Diadema, Brasil1  Sartorelli, Patricia1  Universidade de São Paulo, São Paulo, Brasil1  Silva, Adalberto M. da1  Universidade Federal de Alfenas, Alfenas, Brasil1  Lago, João Henrique G.1  Stefani, Hélio A.1  Instituto Adolfo Lutz, São Paulo, Brasil1 
关键词: Schinus terebinthifolius Raddi;    Anacardiaceae;    trypanocidal activity.;   
DOI  :  10.1590/S0100-40422012000400017
学科分类:化学(综合)
来源: Sociedade Brasileira de Quimica
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【 摘 要 】

Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.

【 授权许可】

Unknown   

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