In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

Química Nova

Guadagnin, Rafael C.¹  Soares, Marisi G.¹  Tempone, André G.¹  Santana, Jefferson S.¹  Universidade Federal de Viçosa, Brasil¹  Pinto, Érika G.¹  Universidade Federal de São Paulo, Diadema, Brasil¹  Sartorelli, Patricia¹  Universidade de São Paulo, São Paulo, Brasil¹  Silva, Adalberto M. da¹  Universidade Federal de Alfenas, Alfenas, Brasil¹  Lago, João Henrique G.¹  Stefani, Hélio A.¹  Instituto Adolfo Lutz, São Paulo, Brasil¹ 

关键词: Schinus terebinthifolius Raddi;    Anacardiaceae;    trypanocidal activity.;   

DOI  :  10.1590/S0100-40422012000400017

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.

【 授权许可】

Unknown