Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae)

Química Nova

Geraldo H. Silva²  Camila M. De Oliveira²  Helder L. Teles²  Vanderlan Da S. Bolzani²  Angela R. Araujo²  Ludwig H. Pfenning¹  Maria Claudia M. Young¹  Claudio M. Costa-neto¹  Renato Haddad¹  Marcos N. Eberlin¹ 

[1] ,Universidade Estadual Paulista Instituto de Química Araraquara SP ,Brasil

关键词: Xylaria sp.;    Piper aduncum;    endophytic fungus;   

DOI  :  10.1590/S0100-40422010001000006

来源: SciELO

【 摘 要 】

A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.

【 授权许可】

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