Química Nova | |
Cytochalasins produced by Xylaria sp., an endophytic fungus from Piper aduncum | |
Pfenning, Ludwig H.1  Silva, Geraldo H.1  Universidade Estadual Paulista, Araraquara, Brasil1  Araujo, Angela R.1  Universidade Federal de Lavras, Lavras, Brasil1  Haddad, Renato1  Universidade Estadual de Campinas, Campinas, Brasil1  Oliveira, Camila M. de1  Instituto de Botânica, São Paulo, Brasil1  Eberlin, Marcos N.1  Young, Maria Claudia M.1  Universidade de São Paulo, Ribeirão Preto, Brasil1  Teles, Helder L.1  Costa-Neto, Claudio M.1  Bolzani, Vanderlan da S.1  | |
关键词: Xylaria sp.; Piper aduncum; endophytic fungus.; | |
DOI : 10.1590/S0100-40422010001000006 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.
【 授权许可】
Unknown
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