Cytochalasins produced by Xylaria sp., an endophytic fungus from Piper aduncum

Química Nova

Pfenning, Ludwig H.¹  Silva, Geraldo H.¹  Universidade Estadual Paulista, Araraquara, Brasil¹  Araujo, Angela R.¹  Universidade Federal de Lavras, Lavras, Brasil¹  Haddad, Renato¹  Universidade Estadual de Campinas, Campinas, Brasil¹  Oliveira, Camila M. de¹  Instituto de Botânica, São Paulo, Brasil¹  Eberlin, Marcos N.¹  Young, Maria Claudia M.¹  Universidade de São Paulo, Ribeirão Preto, Brasil¹  Teles, Helder L.¹  Costa-Neto, Claudio M.¹  Bolzani, Vanderlan da S.¹ 

关键词: Xylaria sp.;    Piper aduncum;    endophytic fungus.;   

DOI  :  10.1590/S0100-40422010001000006

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.

【 授权许可】

Unknown