Quimica nova | |
Cytochalasins produced by Xylaria sp., an endophytic fungus from Piper aduncum | |
Young, Maria Claudia M.1  Silva, Geraldo H.2  Araujo, Angela R.2  Teles, Helder L.2  Oliveira, Camila M. de2  Bolzani, Vanderlan da S.2  Eberlin, Marcos N.3  Haddad, Renato3  Pfenning, Ludwig H.4  Costa-Neto, Claudio M.5  | |
[1] Instituto de Botânica, São Paulo, Brasil;Universidade Estadual Paulista, Araraquara, Brasil;Universidade Estadual de Campinas, Campinas, Brasil;Universidade Federal de Lavras, Lavras, Brasil;Universidade de São Paulo, Ribeirão Preto, Brasil | |
关键词: Xylaria sp.; Piper aduncum; endophytic fungus.; | |
DOI : 10.1590/S0100-40422010001000006 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
A chemical studyon the EtOAc extract produced by Xylaria sp., an endophytic fungus fromPiper aduncum, resulted in the isolation of a new cytochalasin 1,along with five known 19,20-epoxycytochalasin D (2), C (3), N(4), Q (5), and R (6). The 1-6 wereevaluated against the fungi C. cladosporioides and C. sphaerospermumand only 5 showed weak activity. The cytotoxicity in vitro againstHeLA and CHO cells lines were investigated and the cytochalasins 2-4,and 6 showed a strong activity against HeLA. The DNAdamaging activityof 1-6 were also investigated against mutant strains ofS. cerevisiae.
【 授权许可】
CC BY
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