Cytochalasins produced by Xylaria sp., an endophytic fungus from Piper aduncum

Quimica nova

Young, Maria Claudia M.¹  Silva, Geraldo H.²  Araujo, Angela R.²  Teles, Helder L.²  Oliveira, Camila M. de²  Bolzani, Vanderlan da S.²  Eberlin, Marcos N.³  Haddad, Renato³  Pfenning, Ludwig H.⁴  Costa-Neto, Claudio M.⁵ 

[1] Instituto de Botânica, São Paulo, Brasil;Universidade Estadual Paulista, Araraquara, Brasil;Universidade Estadual de Campinas, Campinas, Brasil;Universidade Federal de Lavras, Lavras, Brasil;Universidade de São Paulo, Ribeirão Preto, Brasil

关键词: Xylaria sp.;    Piper aduncum;    endophytic fungus.;   

DOI  :  10.1590/S0100-40422010001000006

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A chemical studyon the EtOAc extract produced by Xylaria sp., an endophytic fungus fromPiper aduncum, resulted in the isolation of a new cytochalasin 1,along with five known 19,20-epoxycytochalasin D (2), C (3), N(4), Q (5), and R (6). The 1-6 wereevaluated against the fungi C. cladosporioides and C. sphaerospermumand only 5 showed weak activity. The cytotoxicity in vitro againstHeLA and CHO cells lines were investigated and the cytochalasins 2-4,and 6 showed a strong activity against HeLA. The DNAdamaging activityof 1-6 were also investigated against mutant strains ofS. cerevisiae.

【 授权许可】

CC BY