Química Nova | |
Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae) | |
Geraldo H. Silva2  Camila M. De Oliveira2  Helder L. Teles2  Vanderlan Da S. Bolzani2  Angela R. Araujo2  Ludwig H. Pfenning1  Maria Claudia M. Young1  Claudio M. Costa-neto1  Renato Haddad1  Marcos N. Eberlin1  | |
[1] ,Universidade Estadual Paulista Instituto de Química Araraquara SP ,Brasil | |
关键词: Xylaria sp.; Piper aduncum; endophytic fungus; | |
DOI : 10.1590/S0100-40422010001000006 | |
来源: SciELO | |
【 摘 要 】
A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.
【 授权许可】
CC BY-NC
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