Química Nova | |
Atividade antiproliferativa de Sloanea garckeana K. Schum. | |
Adriano Lopes Romero2  Álvaro Fontana2  Cleuza Conceição Da Silva2  Maria Conceição De Souza1  João Ernesto De Carvalho1  Emiret O. Faria1  Lucilia Kato1  Cecília M. A. De Oliveira1  | |
[1] ,Universidade Estadual de Maringá Departamento de Química Maringá PR ,Brasil | |
关键词: Sloanea garkeana; Elaeocarpaceae; 3-O-methyl ellagic acid-4'-O-α-L-rhamnoside; | |
DOI : 10.1590/S0100-40422008000600016 | |
来源: SciELO | |
【 摘 要 】
The crude methanol extract and hexane, ethyl acetate, chloroform and methanol fractions from leaves of S. garckeana were examined in vitro for their antiproliferative activity on MCF-7, NCI-ADR, NCI-460, UACC-62, 786-0, OVCAR-03, PCO-3 and HT-29 human cancer cell lines. Among the assayed fractions, the ethyl acetate fraction showed to be cytotoxic against 786-0, UACC-62, OVCAR-03 and NCI-ADR cell lines with IC50 values of 12 µg/mL, 42 µg/mL, 53 µg/mL and 51 µg/mL, respectively. Through fractionation and isolation procedures compound (1) was obtained from the EtOAc fraction and its structure was elucidated by spectral techniques.
【 授权许可】
CC BY-NC
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