Antiproliferative activity of Sloanea garckeana K. Schum.

Quimica nova

Carvalho, João Ernesto de¹  Silva, Cleuza Conceição da²  Romero, Adriano Lopes²  Fontana, Álvaro²  Souza, Maria Conceição de²  Oliveira, Cecília M. A. de³  Kato, Lucilia³  Faria, Emiret O.³ 

[1] Centro Pluridisciplinar de Pesquisas Químicas Biológicas e Agrárias, Campinas, Brasil;Universidade Estadual de Maringá, Maringá, Brasil;Universidade Federal de Goiás, Goiânia, Brasil

关键词: Sloanea garkeana;    Elaeocarpaceae;    3-;    O-;    methyl ellagic acid-;    4'-;    O-;    α;    -;    L-;    rhamnoside.;   

DOI  :  10.1590/S0100-40422008000600016

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The crude methanol extract and hexane, ethylacetate, chloroform and methanol fractions from leaves of S. garckeanawere examined in vitro for their antiproliferative activity on MCF-7,NCI-ADR, NCI-460, UACC-62, 786-0, OVCAR-03, PCO-3 and HT-29 human cancer celllines. Among the assayed fractions, the ethyl acetate fraction showed to becytotoxic against 786-0, UACC-62, OVCAR-03 and NCI-ADR cell lines with IC50values of 12 µg/mL, 42 µg/mL, 53 µg/mLand 51 µg/mL, respectively. Through fractionation and isolationprocedures compound (1) was obtained from the EtOAc fraction and itsstructure was elucidated by spectral techniques.

【 授权许可】

CC BY