Antiproliferative activity of Sloanea garckeana K. Schum.

Química Nova

Oliveira, Cecília M. A. de¹  Universidade Federal de Goiás, Goiânia, Brasil¹  Silva, Cleuza Conceição da¹  Romero, Adriano Lopes¹  Carvalho, João Ernesto de¹  Centro Pluridisciplinar de Pesquisas Químicas Biológicas e Agrárias, Campinas, Brasil¹  Fontana, Álvaro¹  Kato, Lucilia¹  Souza, Maria Conceição de¹  Universidade Estadual de Maringá, Maringá, Brasil¹  Faria, Emiret O.¹ 

关键词: Sloanea garkeana;    Elaeocarpaceae;    3-;    O-;    methyl ellagic acid-;    4'-;    O-;    α;    -;    L-;    rhamnoside.;   

DOI  :  10.1590/S0100-40422008000600016

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The crude methanol extract and hexane, ethyl acetate, chloroform and methanol fractions from leaves of S. garckeana were examined in vitro for their antiproliferative activity on MCF-7, NCI-ADR, NCI-460, UACC-62, 786-0, OVCAR-03, PCO-3 and HT-29 human cancer cell lines. Among the assayed fractions, the ethyl acetate fraction showed to be cytotoxic against 786-0, UACC-62, OVCAR-03 and NCI-ADR cell lines with IC50 values of 12 µg/mL, 42 µg/mL, 53 µg/mL and 51 µg/mL, respectively. Through fractionation and isolation procedures compound (1) was obtained from the EtOAc fraction and its structure was elucidated by spectral techniques.

【 授权许可】

Unknown