Química Nova | |
Antiproliferative activity of Sloanea garckeana K. Schum. | |
Oliveira, Cecília M. A. de1  Universidade Federal de Goiás, Goiânia, Brasil1  Silva, Cleuza Conceição da1  Romero, Adriano Lopes1  Carvalho, João Ernesto de1  Centro Pluridisciplinar de Pesquisas Químicas Biológicas e Agrárias, Campinas, Brasil1  Fontana, Álvaro1  Kato, Lucilia1  Souza, Maria Conceição de1  Universidade Estadual de Maringá, Maringá, Brasil1  Faria, Emiret O.1  | |
关键词: Sloanea garkeana; Elaeocarpaceae; 3-; O-; methyl ellagic acid-; 4'-; O-; α; -; L-; rhamnoside.; | |
DOI : 10.1590/S0100-40422008000600016 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
The crude methanol extract and hexane, ethyl acetate, chloroform and methanol fractions from leaves of S. garckeana were examined in vitro for their antiproliferative activity on MCF-7, NCI-ADR, NCI-460, UACC-62, 786-0, OVCAR-03, PCO-3 and HT-29 human cancer cell lines. Among the assayed fractions, the ethyl acetate fraction showed to be cytotoxic against 786-0, UACC-62, OVCAR-03 and NCI-ADR cell lines with IC50 values of 12 µg/mL, 42 µg/mL, 53 µg/mL and 51 µg/mL, respectively. Through fractionation and isolation procedures compound (1) was obtained from the EtOAc fraction and its structure was elucidated by spectral techniques.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912050594237ZK.pdf | 120KB | download |