Atividade antiproliferativa de Sloanea garckeana K. Schum.

Química Nova

Adriano Lopes Romero²  Álvaro Fontana²  Cleuza Conceição Da Silva²  Maria Conceição De Souza¹  João Ernesto De Carvalho¹  Emiret O. Faria¹  Lucilia Kato¹  Cecília M. A. De Oliveira¹ 

[1] ,Universidade Estadual de Maringá Departamento de Química Maringá PR ,Brasil

关键词: Sloanea garkeana;    Elaeocarpaceae;    3-O-methyl ellagic acid-4'-O-α-L-rhamnoside;   

DOI  :  10.1590/S0100-40422008000600016

来源: SciELO

【 摘 要 】

The crude methanol extract and hexane, ethyl acetate, chloroform and methanol fractions from leaves of S. garckeana were examined in vitro for their antiproliferative activity on MCF-7, NCI-ADR, NCI-460, UACC-62, 786-0, OVCAR-03, PCO-3 and HT-29 human cancer cell lines. Among the assayed fractions, the ethyl acetate fraction showed to be cytotoxic against 786-0, UACC-62, OVCAR-03 and NCI-ADR cell lines with IC50 values of 12 µg/mL, 42 µg/mL, 53 µg/mL and 51 µg/mL, respectively. Through fractionation and isolation procedures compound (1) was obtained from the EtOAc fraction and its structure was elucidated by spectral techniques.

【 授权许可】

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