Química Nova | |
Efeito da composição do solvente sobre a estabilidade de proteínas em soluções aquosas | |
Lúbia Cristina Fonseca1  Natássia Caroline Resende Corrêa1  Mario Da Silva Garrote-filho1  Cleine Chagas Da Cunha1  Nilson Penha-silva1  | |
关键词: chaotropics; protein stability; osmolytes; | |
DOI : 10.1590/S0100-40422006000300024 | |
来源: SciELO | |
【 摘 要 】
A protein presents a native (N) macro state, which is functionally active, in equilibrium with the denatured (D) macro state, which is devoid of biological activity. An ensemble of microstates forms each macrostate. The denatured state comprises a greater ensemble of microstates than the native macrostate. The N-D equilibrium can be affected by several factors, that comprise the purity of the water, temperature, pH and solute concentration. This work discusses the influence of osmolytes and chaotropics on the N-D equilibrium in aqueous solutions.
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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