期刊论文详细信息
Química Nova | |
Effects of the solvent composition on the stability of proteins in aqueous solutions | |
Cunha, Cleine Chagas da1  Garrote-Filho, Mario da Silva1  Corrêa, Natássia Caroline Resende1  Penha-Silva, Nilson1  Fonseca, Lúbia Cristina1  | |
关键词: chaotropics; protein stability; osmolytes.; | |
DOI : 10.1590/S0100-40422006000300024 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
A protein presents a native (N) macro state, which is functionally active, in equilibrium with the denatured (D) macro state, which is devoid of biological activity. An ensemble of microstates forms each macrostate. The denatured state comprises a greater ensemble of microstates than the native macrostate. The N-D equilibrium can be affected by several factors, that comprise the purity of the water, temperature, pH and solute concentration. This work discusses the influence of osmolytes and chaotropics on the N-D equilibrium in aqueous solutions.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912050593529ZK.pdf | 229KB | download |