Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malaria

Memórias do Instituto Oswaldo Cruz

Leonardo Jm Carvalho²  Salma G Oliveira¹  Francisco A Alves¹  Maria Co Brígido¹  José Apc Muniz¹  Claudio T Daniel-ribeiro² 

[1] ,Instituto Oswaldo Cruz Departamento de Imunologia Laboratório de Pesquisas em MaláriaRio de Janeiro RJ ,Brasil

关键词: Aotus infulatus;    Plasmodium falciparum;    malaria;    primate model;   

DOI  :  10.1590/S0074-02762000000300011

来源: SciELO

【 摘 要 】

Aotus is one of the WHO-recommended primate models for studies in malaria, and several species can be infected with Plasmodium falciparum or P. vivax. Here we describe the successful infection of the species A. infulatus from eastern Amazon with blood stages of P. falciparum. Both intact and splenectomized animals were susceptible to infection; the intact ones were able to keep parasitemias at lower levels for several days, but developed complications such as severe anemia; splenectomized monkeys developed higher parasitemias but no major complications. We conclude that A. infulatus is susceptible to P. falciparum infection and may represent an alternative model for studies in malaria.

【 授权许可】

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