Severe anemia affects both splenectomized and non-splenectomized Plasmodium falciparum-infected Aotus infulatus monkeys

Memórias do Instituto Oswaldo Cruz

Leonardo J De Moura Carvalho¹  Francisco Acácio Alves¹  Salma Gomes De Oliveira¹  Rodrigo Del Rio Do Valle¹  Andréa A Morais Fernandes¹  José A Pereira Carneiro Muniz¹  Claudio T Daniel-ribeiro¹ 

关键词: malaria;    Plasmodium falciparum;    Aotus infulatus;    primate model;   

DOI  :  10.1590/S0074-02762003000500016

来源: SciELO

【 摘 要 】

Severe anemia is the earliest and a frequently fatal complication of Plasmodium falciparum infection. Here we describe Aotus infulatus as a primate model suitable to study this malaria complication. Both non-splenectomized and splenectomized monkeys receiving different inocula of P. falciparum FVO strain presented large (> 50%) decreases in hematocrit values during infection. Non-splenectomized animals were able to control parasite growth (parasitemia did not exceed 4%), but they had to be treated because of severe anemia. Three of 4 splenectomized monkeys did not control parasitemia and were treated, but developed severe anemia after treatment when presenting a negative blood film. Destruction of parasitized red blood cells alone cannot account for the degree of anemia. Non-splenectomized monkeys repeatedly infected with homologous parasites became rapidly and progressively resistant to reinfection and to the development of severe anemia. The data presented here point to A. infulatus as a suitable model for studying the pathogenesis of severe malarial infection.

【 授权许可】

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